Tupelo /ˈtuːpəloʊ/ is the county seat and the largest city of Lee County, Mississippi, United States. The seventh-largest city in the state, it is situated in Northeast Mississippi, between Memphis, Tennessee, and Birmingham, Alabama. It is accessed by Interstate 22. As of the 2010 census, the population was 34,546, with the surrounding counties of Lee, Pontotoc and Itawamba supporting a population of 139,671Tupelo was the first city to gain an electrical power grid under President Franklin D. Roosevelt's program of the Tennessee Valley Authority construction of facilities during the Great Depression. The city is also the birthplace of singer Elvis Presley.